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Allergic Reactions to Unknown Ingredients

Users on Reddit have reported experiences with allergic reactions to what they suspect are unknown or inactive ingredients in GLP-1 medications. These reactions can manifest in various ways.

Experiences with Allergic Reactions to Unknown Ingredients:

  • One user described developing allergies to something in the inactive ingredients of synthetic thyroid medications, which presented as "flu symptoms (like having the flu every day) as well as intense sinusitis so painful that I could barely function. "[1] While this was for a thyroid medication, the user shared this in a GLP-1 discussion, implying a similar concern about inactive ingredient allergies.

  • Another user on a GLP-1 medication reported they "had started getting allergic reaction to the injections. "[2] They also mentioned needing to take an antihistamine regularly. [2]


Remedies and Preventions Recommended:

  • Switching Medication Formulation: The user who experienced allergy symptoms with synthetic thyroid medication was switched to "a non-synthetic natural one made from desiccated pork," which resolved their issues. [1]

  • Antihistamines: One user mentioned they "Need to take regular gavascon, fiber and antihistamine" while on their GLP-1 medication, suggesting antihistamines might be used to manage allergic reactions. [2]

  • Discontinuation/Seeking Medical Advice: The prescribing information for Wegovy (a GLP-1) notes that "Anaphylactic reactions and angioedema have been reported postmarketing. Discontinue WEGOVY if suspected and promptly seek medical advice (5. 6). "[3] This indicates that if a hypersensitivity reaction is suspected, the medication should be stopped and medical attention sought.


It's important to note that if an allergic reaction is suspected, users should consult their healthcare provider immediately.
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