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Diarrhea / Loose Stool

Users on Reddit report varied experiences with diarrhea or loose stools while taking GLP-1 medications, with some experiencing it as a side effect and others, particularly those with IBS-D, finding relief from pre-existing diarrhea.

Experiences with Diarrhea / Loose Stool:

  • Some users experience diarrhea as a side effect. One user on Zepbound reported, "I have abdominal pain, nausea, diarrhea and now vomiting in all doses. "[2] Another user mentioned their bowel movements include one that is "like normal that turns to diarrhea. "[4]

  • A user on Saxenda described a severe experience: "Had the worst bloated tummy I’ve ever had while throwing up and having diarrhea. "[6]

  • Another user on Ozempic mentioned experiencing "Either constatation or extremely loose stools. "[7]

  • Some users with pre-existing conditions like IBS-D (Irritable Bowel Syndrome with Diarrhea) have found that GLP-1s can help. One user stated, "Constipation is often a side effect of GLP-1 so it can help with IBS-D by resolving diarrhea and leading to more regular bowel movements. "[1] Another user with IBS-D who also struggled with chronic diarrhea found the constipating effect of Ozempic to be a benefit, stating, "I can sometimes use a lower dose of the medication (colesevelam) that helps with the trots, as a result. "[5]

  • A user on Metformin (often discussed alongside GLP-1s for PCOS and diabetes) reported, "Metformin gave me the worst diarrhoea I’ve ever had in my life... I have had zero side effects with GLP1s and my quality of life has increased dramatically. "[11]

  • One user on Saxenda experienced "super painful explosive diarrhea. " [16]

  • A user on Zepbound who also has POTS (Postural Orthostatic Tachycardia Syndrome) mentioned experiencing diarrhea and vomiting when they increased their dose too quickly and got dehydrated. [17]

  • A user taking Metformin reported it "does give you bad diarrhea if you eat too many carbs or just in general sometimes though. "[18]


Remedies and Preventions Recommended:

  • Dietary Adjustments:

  • Avoiding certain foods: One user noted that side effects like diarrhea can be worse with "fried fatty greasy foods. very sweet and processed food also tend to make it worse. "[15] Another user on compounded semaglutide said their only side effects, including being "super constipated" initially, occurred when they ate the wrong food, specifically mentioning, "When they say don't eat heavy carbs, it's not a joke. Stay away, far away. I was miserable for almost a week and a half because I messed up and are pasta 3 days in a row. "[3]

  • Hydration:

  • Drinking plenty of water is frequently recommended. One user stated, "It really seems to me that a huge percentage of side effects people experience with these meds could be headed off by simply increasing fluid intake aggressively. "[10] Another mentioned, "when I drink a ton of water (around 135 ounces), I don’t have a lot of side effects. "[12]

  • Supplements/Medications:

  • Probiotics: "Daily probiotic supplements have helped tremendously with my sulfur-gas and bowel issues. I highly recommend this for anyone on one of these drugs. "[8]

  • Guar Gum: A user with IBS-M experiencing both constipation and loose stools mentioned, "looking into getting some guar gum supplement as that is supposed to be good for both diarrhea and constipation! Sunfiber seems to be a decent brand. "[6]

  • Pepto-Bismol: For sulfur burps that led to vomiting and to remedy bathroom problems, one user found Pepto-Bismol cherry chewables to be a "godsend. " [3]


It's important to note that while some experience diarrhea, constipation is a more commonly reported side effect of GLP-1 medications.
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