Users on Reddit, particularly those with PCOS, report experiencing improved menstrual regularity while on GLP-1 medications. Many attribute this to hormone regulation and weight loss facilitated by the medication.

Experiences with Improved Menstrual Regularity:

• Several users with PCOS have noted their periods becoming regular after starting GLP-1s. One user who used to get a period once every four months stated, "I started tirzepatide recently and now It’s been two months in a row that I’ve gotten my period. "[1] Another shared, "My period is regular now... actually predictable! "[3]


• A user mentioned their OB-GYN confirmed that "a number of her PCOS patients have noticed their cycle become regulated from glp1s. "[2]


• Another user reported, "Only time I've ever been regular is while on these meds. First came days after my first shot. Spent a few months every 4-6 weeks and now routinely 30 days. "[5]


• Someone on Mounjaro since January said, "it immediately regulated my periods. i went from super irregular getting it every 2 months and sometimes even longer to regular like clockwork. "[7]


• A user on Wegovy shared, "my hormones feel amazing. My periods are regular and less painful and heavy. I’m ovulating regularly and I feel amazing outside of my period. "[13]


• Similarly, another user on Mounjaro/semaglutide for about 5. 5 months noted, "My periods also started to regulate and I had wayyyy more energy! "[12]


• One user on Tirzepatide (Zepbound/Mounjaro) for 11 months stated, "My labs and hormone levels are perfect, I get my periods regularly (and they’re much much more manageable). "[15]


• A user on Ozempic for 14 months, after struggling with inconsistent periods (max 2 a year), reported, "two weeks after I started, I got one? I was shocked. The next month, I got another. Then the next month another. And they got more consistent from there. Went from every 40 days down to every 28-30days and so consistent, I’m tracking them down to the morning or afternoon they’ll start. "[16]


• A user with adenomyosis on Mounjaro for 2. 5 months experienced their cycles becoming regular again: "While on Mounjaro, my cycles became regular again, less heavy periods, hormones stabilized, and got pregnant after the 2nd month. "[10]


• Another user with adenomyosis reported significant improvement after three months on a GLP-1: "month three and I no longer need transexamic acid and managed to function like a normal person. Still have cramps and swelling, but normal period bleeding, no flooding and not even heavy. "[11]

Reasons Attributed for Regularity:

• Many users and some doctors suggest that the regulation is due to the medication helping to balance hormones, especially in individuals with PCOS. One comment explained, "There’s a correlation with weight loss and PCOS management and the regulation of periods. It means you’re balancing your hormones and it’s a great indication that you’re doing things pretty well! "[17] Another user echoed this: "This is because PCOS is an endocrine disease, not a gynecological disease. You’re regulating your hormones and reducing your insulin resistance, so your ovaries can function better. "[6]


• Weight loss achieved on GLP-1s is also cited as a factor. A user with Stage 4 endo who lost 70lbs on Mounjaro said their "endo was sooooooo well controlled" and periods were "cake," attributing it to "losing the weight/estrogen dominance leveling out. "[8]


• Improved insulin resistance is another key factor mentioned: "Any time my insulin isn't whack I have normal periods. "[9]

Other Menstrual Changes Noted:

• Some users experienced changes even with an IUD: "That’s been happening to me and I have an IUD. It’s not a long, heavy period but still pretty consistent. "[4]


• One user on Ozempic noted a change in their cycle when the dosage increased: "Side effect varied from having an early period one time - cycle changed when I increased dosage on ozempic from . 5 to 1mg... my period has been steady. "[18]


• A user on Mounjaro mentioned, "Since everything on earth impacts menstruation, I had bleeding issues after starting it. Apparently that’s pretty common; it’s not a direct side effect, but a result of so many hormonal/system changes. "[14]

Remedies/Preventions:

The dataset primarily focuses on the positive outcome of improved regularity, especially for those with pre-existing irregularities like in PCOS. Therefore, specific remedies or preventions for achieving* regularity (beyond taking the GLP-1 itself and its effects on hormones and weight) are not extensively discussed. The medication itself is seen as the intervention leading to regularity for these users.

• One user mentioned that if they went off GLP-1s, they might consider progesterone to keep their cycle regular: "I haven’t been on a GLP-1, but I do take progesterone the first 10 days of each month to help regulate my period... So that could be an option too potentially if you do go off of it to help keep your cycle regular. "[19]

It is important to note that while many report positive changes, some users with conditions like adenomyosis or endometriosis have experienced no change or even worsening of their period symptoms.