Inconsistent Dosing/Potency
Users on Reddit have reported experiences with inconsistent dosing or potency of GLP-1 medications, particularly when comparing branded medications (like Ozempic, Wegovy, Mounjaro, Zepbound) with compounded versions. Some users also discuss the importance of proper dose titration to manage effects and side effects.
Experiences with Inconsistent Dosing/Potency:
A user shared their experience with Henry Meds' compounded semaglutide, noting, "I was on Ozempic for 1. 5 years before my healthcare denied coverage at the same low dose with no changes or problems but I’ve gained weight in the last few weeks after being on Henry Meds semi for 2. 5 months. So I really don’t think it is the same. "[3]
Another user on compounded semaglutide from Henry Meds, fulfilled by Healthwarehouse. com (from BPI labs), found it effective: "For me it worked well so far. No other side effects than as described by the doctor. Down 10lbs. "[4]
One user taking the Ozempic pill (Rybelsus) reported, "Didn't work very well, like 2 days out of 6 weeks on full strength... Not worth it since it didn't reduce my appetite on only 2 days. "[5] They also mentioned, "I hear the injection has less side effects. "[6]
A user on Ozempic for 18 months still experienced "bad nausea & constipation," suggesting that for some, the effects (or side effects) of a particular dose don't necessarily wane or become more consistent over time. [7]
There are discussions about the chemical forms of semaglutide, with some users and sources suggesting that compounded pharmacies might use salt forms of semaglutide, while FDA-approved versions use the base form. The FDA has warned that "the salt forms are different active ingredients than is used in the approved drugs. "[8]
Remedies and Preventions Recommended:
Another user shared, "Through managing my own doses and ignoring BUD I've stayed at 1-2mg per week for about 1. 5 years of Tirzepatide... In my honest opinion I think we start our doses of GLP1s too high for some people. "[10]
"The key is to find the best dose for your BODY, it isn’t about getting to the highest dose to reach max weight loss... Try going down until side effects are non-existent or minimal.. and tolerable! "[11]
A user with dysautonomia mentioned their doctor wanting to try a "microdosing" approach with a dose below the standard starting dose to avoid symptoms. [12]
When switching between GLP-1 drugs, it's recommended to start at the lowest dose of the new drug, rather than an equivalent dose of the previous one. "if you switch GLP-1 drugs you have to start at the bottom, so despite the Liraglutide dose of you switch to Tirzepatide you start at 2. 5mg/wk and tittate up. "[13]
Some users adjust their dose based on their plans, for example, taking a "Lower dose for vacations because I’m a foodie. " This is noted as easier with compounded versions. [14]
Choosing Medication Source:
Some users express more trust in FDA-approved brand-name medications over compounded versions due to concerns about consistency and quality control. One user's doctor told them "the compound stuff was crap and to try Zepbound. "[1]
However, others find compounded versions effective and more affordable, especially when insurance doesn't cover brand-name options. "The majority of people who are on GLP-1s are likely receiving compounded medications... the compounded route is much less stress. They don’t generally have supply constraints and the patients get their meds. And it’s a fraction of the cost. "[15]
Understanding Dosage and Effects:
One user noted that their doctor said, "if you don’t get that sick feeling then there is a higher chance of no response as the two parts of the brain that responsible for nausea and hunger are next to each other (apparently). "[16] This suggests that a lack of initial side effects might sometimes correlate with lower efficacy for some individuals, though this is anecdotal.
A user on Ozempic mentioned, "I have doubts that at 0. 25 that there is much effect at all unless you are under 100 pounds. There was no real change until . 5 and at . 75 have seen the real difference, may dial back to . 6 just to not lose too much weight. "[17] This highlights individual variability in response to different doses.
It's important to note that experiences with GLP-1 medications, including their potency and side effects, can vary significantly from person to person. Consulting with a healthcare provider is crucial for determining the appropriate medication, dosage, and management plan.
Experiences with Inconsistent Dosing/Potency:
- Some users feel that compounded GLP-1s may not be as effective or may have more side effects.
Remedies and Preventions Recommended:
- Proper Titration and Finding the Right Dose:
- Many users emphasize the importance of starting with a low dose and titrating up slowly.
It's important to note that experiences with GLP-1 medications, including their potency and side effects, can vary significantly from person to person. Consulting with a healthcare provider is crucial for determining the appropriate medication, dosage, and management plan.