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Injection Site Reactions

Users on Reddit report experiencing injection site reactions (ISRs) while on GLP-1 medications, with symptoms varying in presentation and duration.

Experiences with Injection Site Reactions:

  • Some users describe the reaction as an itchy, red bump similar to a mosquito bite that may fade into a scar-like mark. One user asked, "Anyone that’s taking glp1 experience their injection site getting itchy a few days after injecting? This didn’t happen to me the first 2 months, but now I’m on my 3rd month and get a little red bump almost like a mosquito bite and then it fades away a few days later into like a scar. "[1]

  • Another user confirmed this experience: "Yes just finished 12th dose and noticed a few back these marks that I thought were bites. They do go away. "[3]

  • One user noted the onset of these reactions after a dosage increase: "Welcome to the club. I have been getting them since I started 7. 5mg on March 13, 2024. A year later, I'm still getting them. I'm on 12. 5mg. The scar will disappear. "[2]

  • A user described their first ISR: "Yes, got my first one this week with my first 7. 5mg. Mine is blotchy red with an irregular shape and slightly itchy. "[5]

  • Another user mentioned developing an "allergic reaction to the injections. "[7]

  • It's noted that ISRs are a known side effect, with one user stating, "It’s called an injection site reaction. It happens in about 8% of users. "[4]

  • Some users experience bruising. One user mentioned, "I have 3 very light bruises, but they’re slowly fading away. "[6]


Remedies and Preventions Recommended:

  • Topical Treatments: Some users suggest applying anti-itch or antihistamine ointments. One comment mentioned, "I think some people apply anti-itch or antihistamine ointments to control it after the injection. "[4]

  • Rotating Injection Sites: Users discuss the importance of changing where they inject the medication. One user asked, "Are you moving the shots around or going to the same spot week after week? "[8] The original poster replied, "I move them around! I switch from both arms to my stomach every week. "[6]

  • Antihistamines: One user stated they "Need to take regular gavascon, fiber and antihistamine. "[7]

  • Changing Injection Location (e. g. , to thigh): Some users found that changing the injection site to the thigh helped reduce symptoms. One user said, "My doctor suggested injecting into the thigh for less symptoms! "[9] Another exclaimed, "Yepppppppp THIGH INJECTIONS have changed my ENTIRE experience 🙌🏽🙌🏽🙌🏽"[10] and "The thigh has been my go to since after I got sick as hell injecting in my stomach. I’m sticking to it too lol. "[11]


It's also mentioned that for some, the marks or scars from ISRs do eventually fade.
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