Irregular Heartbeat / Atrial Fibrillation (AFIB)
Users on Reddit have reported a range of experiences concerning irregular heartbeat and Atrial Fibrillation (AFIB) while on GLP-1 medications, with some also discussing increased heart rate and other cardiovascular effects. They have also shared some remedies and preventative measures.
Experiences with Irregular Heartbeat, AFIB, and Increased Heart Rate:
Increased heart rate is a frequently mentioned side effect. A user shared information from studies indicating that GLP-1 receptor agonists (GLP-1 RAs) "can indeed affect resting heart rate. Studies have shown that these medications can increase heart rate... Short-acting GLP-1 RAs... modest and transient increase in heart rate, typically 1-3 beats per minute (bpm)... long-acting GLP-1 RAs... more pronounced and sustained increases, ranging from 6-10 bpm. "[2] This user also noted, "The mechanism behind this increase is not fully understood but may involve direct effects on the sinus node or stimulation of the sympathetic nervous system. "[2]
Another user on Ozempic stated, "One of the possible side effects is a fast heart rate as well. "[3]
Users with pre-existing dysautonomia conditions like POTS (Postural Orthostatic Tachycardia Syndrome) or IST (Inappropriate Sinus Tachycardia) reported that GLP-1 medications could exacerbate their symptoms. One user said, "I didn't realize I had POTS until I was on one... Keep in mind that these meds can dehydrate you easily, so POTS will likely be worse than usual on it. "[4] Another with suspected IST mentioned, "I think losing weight lowers my BP, causing my heart rate to go up when I stand. "[5]
A user shared an anecdotal report: "I do have a friend who was hospitalized due to Ozempic exacerbating a heart condition. "[3]
A serious cardiovascular event was reported by a medical professional concerning a patient who developed an NSTEMI (a type of heart attack). The user explained, "Dose change of ozempic caused severe vomiting and diarrhea that led to dehydration... Their dehydration was so significant, and they became so severely hemoconcentrated that they coagulated their LAD. "[6]
Some users experienced symptoms that could be perceived as heart-related, such as "occasional shortness of breath, light headed," though in one instance, this was diagnosed as a panic attack after a hospital visit. [7]
Remedies and Preventions Recommended by Users:
"Keep in mind that these meds can dehydrate you easily, so POTS will likely be worse than usual on it. "[4]
One user on Mounjaro stated, "I do have to make sure I hydrate, take fiber and electrolytes. "[8]
Electrolytes: Often recommended in conjunction with hydration.
A user with POTS mentioned the importance of "water/electrolytes". [9]
"I do have to make sure I hydrate, take fiber and electrolytes. "[8]
Monitoring Heart Rate: A user shared prescribing information for Wegovy, which includes the advice to "Monitor heart rate at regular intervals (5. 8). "[10]
Dose Management: Some users found that starting with lower doses or titrating slowly helped manage side effects.
A user with POTS reported, "I met with my MD and we decided to start at 2. 5 again. I am on 5 mg again and it's going well," after experiencing severe sickness on a higher dose of Zepbound. [11]
Medical Consultation: Users stress the importance of communicating with healthcare providers.
"And tell your prescriber about it ASAP if anything scares you or lasts for longer than 3-4 days. "[12]
Awareness and Caution: A user advised caution, stating, "if you just want to take it to lose 15 to 30 pounds it’s absolutely not worth it... If you decide to try it please do not ignore any side effects.
Experiences with Irregular Heartbeat, AFIB, and Increased Heart Rate:
- One user, an intensivist, described a severe case where a patient developed "new a fib" following a cascade of complications including pancreatitis and DKA, which were potentially linked to GLP-1 medication.
Remedies and Preventions Recommended by Users:
- Hydration: Staying well-hydrated is frequently emphasized as crucial, particularly for individuals with conditions like POTS or to mitigate general side effects.