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Users on Reddit have reported experiences with kidney stones while on GLP-1 medications and discuss potential links, with a strong emphasis on hydration as a preventative measure.

Experiences with Kidney Stones and Related Kidney Issues:

One user on Zepbound reported, "Recently had some blood in the urine issues traced to Kidney stones. "[1] This user also shared information they found: "one snippet from ‘Semaglutide and Kidney Stones: What You Need to Know’ (published October 31, 2023) suggests a potential association between semaglutide use and an increased risk of developing kidney stones. The exact mechanism is not yet fully understood, but it is believed that semaglutide may affect the composition of urine, leading to the formation of kidney stones. "[1]

Another user commented on the same post, suggesting that kidney stones are a topic of discussion within the community: "Just type kidney stones under the search tab in this sub and see how many people have reported kidney stones. "[2]

Dehydration is frequently mentioned as a concern that can lead to kidney problems. One user, a medical professional, noted that among common serious effects of GLP-1s are "AKI [Acute Kidney Injury] from dehydration. "[3]

Another user mentioned that potential long-term risks of GLP-1 medications include "kidney problems. "[6]

Remedies and Preventions Recommended:

Hydration: This is the most frequently and strongly recommended preventative measure. The user who experienced kidney stones emphasized, "In the meantime....... Hydrate Hydrate Hydrate Hydrate. "[1] Another user stated, "It really seems to me that a huge percentage of side effects people experience with these meds could be headed off by simply increasing fluid intake aggressively. "[4]

Electrolytes: One user mentioned the importance of hydration along with electrolytes: "I do have to make sure I hydrate, take fiber and electrolytes.