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Users on Reddit have shared a range of experiences and information regarding liver health while on GLP-1 medications, including reports of severe liver problems, autoimmune-like injury, discussions on liver enzyme impact, and positive outcomes like fatty liver reversal. Recommendations primarily focus on alcohol consumption.

Experiences with Liver Conditions:

Severe Liver Problems: Some users have reported or seen severe liver complications. One user listed "Liver kidney failure" as one of the worst side effects observed. [1] Another described a complex case where a patient experienced severe vomiting (a known GLP-1 side effect), leading to Boerhaave syndrome; the antibiotics administered for this condition then reportedly caused "fulminant liver failure and pt required transplant. "[2]

Autoimmune Hepatitis-like Injury: A specific concern highlighted is the potential for autoimmune reactions affecting the liver. One user shared the title of a medical abstract: "Autoimmune Hepatitis-like Drug Injury of the Liver Associated with the Glucagon-like Peptide 1 (GLP-1) Agonist Dulaglutide. "[3]

Elevated Liver Enzymes & General Liver Impact (Contrasting Views): There are differing perspectives on the general impact of GLP-1s on liver enzymes and stress.

A Pharm. D. user stated in a post, "Both alcohol and GLP-1 medications can affect liver function, and combining the two can put extra stress on the liver. "[5]

Conversely, another Pharm. D. commented, in response to concerns about liver stress, "Per LiverTox, it [GLP-1 medication] has not been linked with increases in liver enzymes or to cases of clinically apparent liver injury. "[6]

Fatty Liver Reversal (Positive Outcome): On a positive note, GLP-1 medications have been associated with improvements in fatty liver disease. A user mentioned that these drugs are "being shown to reverse early NASH [Non-alcoholic steatohepatitis]. "[4]

Remedies and Preventions Recommended:

Alcohol Consumption: The main preventative measure discussed by users in relation to liver health on GLP-1s concerns alcohol intake. The Pharm. D. who mentioned potential liver stress from combining alcohol and GLP-1s advised, "If you choose to drink alcohol while taking GLP-1 medications, medical experts generally recommend limiting your intake to moderate levels. For women, this means capping intake at one standard drink per day, and for men, two drinks per day. "[5]

Awareness and Monitoring: While not a direct remedy, the discussion around potential autoimmune hepatitis-like injury suggests a need for awareness of this rare but serious adverse event among users and prescribers. No specific user-recommended preventions for this were detailed beyond standard medical vigilance.