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Reduced GLP-1 Effectiveness with Niacinamide (compounded)

Based on the provided Reddit data, there is limited direct user discussion about personal experiences of reduced GLP-1 effectiveness specifically due to compounded Niacinamide. However, one user highlighted a potential issue by sharing information from an external source.

Potential for Reduced Effectiveness:

  • One user shared a link and quoted information from Drugs. com, stating, "Niacinamide may interfere with blood glucose control and reduce the effectiveness of tirzepatide and other diabetic medications. "[1]


Remedies or Preventions Recommended (from the source shared by the user):

  • The same source (Drugs. com, as cited by the user) advises: "Monitor your blood sugar levels closely. You may need a dose adjustment of your diabetic medications during and after treatment with niacinamide. "[1]


No other users in the provided data explicitly shared personal experiences of reduced GLP-1 effectiveness when using Niacinamide-compounded medication, nor did they recommend specific remedies or preventions for this particular issue.
Other discussions in the same thread revolved around why Niacinamide is added to compounds (e. g. , for weight loss acceleration, skin benefits, or to differentiate the product)[2][3][4][5] and side effects like skin breakouts from Niacinamide, with some users considering or switching to compounds without it for those reasons.
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