Skin Hypersensitivity / Allodynia / "Sunburn" Skin Pain
Users on Reddit have reported experiences that align with skin hypersensitivity, and related sensory disturbances while on GLP-1 medications, although terms like "allodynia" or "sunburn skin pain" are not frequently used explicitly. These sensations are often described by users who also have pre-existing conditions like fibromyalgia, where GLP-1s sometimes appear to exacerbate their symptoms.
Experiences with Skin Hypersensitivity and Related Pain:
Another user with Fibromyalgia and CFS/ME reported, "When I first started on Mounjaro for my T2, I had horrible anxiety, fatigue, skin tingling, and even worse temperature dysregulation. "[2]
A medical professional on Reddit mentioned seeing "A painful sensory neuropathy, possibly small-fiber or mixed" as a severe side effect of GLP-1s. [3]
Users with fibromyalgia also report a general worsening of their condition. One said, "I swear my fibro pain (dull and achy) was worse on those meds, especially Ozempic. "[4] Another noted, "yes it made my fibro pain and fatigue worse! "[5]
Intense cold sensations and shivers are also reported. One user described, "And I get what I refer to as \"the shivers. \" I get so cold that I shiver and I have to get into bed, fully clothed, under the comforter. "[6]
Remedies and Preventions Recommended:
Managing Chills and Temperature Sensitivity:
One user recommended, "For the chills, I used a heated blanket and sometimes took a Tylenol. "[4]
Another found relief from magnified chills with "long showers. "[7]
For severe shivers, getting into bed fully clothed under a comforter was a coping mechanism. [6]
Dosage Adjustment:
A user with fibromyalgia who experienced magnified fibro pain stated, "My body can’t handle more than 20, even though I have tried multiple times to acclimate from . 10 to . 25, I just can’t handle the side effects of fibro pain past . 20. I still achieve the weight loss, however it’s a slower process because I’m not taking the higher dosage. "[7]
Another user with fibromyalgia and POTS experiencing autonomic issues suggested, "My recommendations are to go down on the GLP-1. "[8]
Discontinuation for Hypersensitivity: Prescribing information for Wegovy (a semaglutide) includes a warning: "Hypersensitivity Reactions: Anaphylactic reactions and angioedema have been reported postmarketing. Discontinue WEGOVY if suspected and promptly seek medical advice (5. 6). "[9] While this is a general warning, it is relevant for severe hypersensitivity responses.
Experiences with Skin Hypersensitivity and Related Pain:
- Some users with fibromyalgia describe intense sensory experiences.
Remedies and Preventions Recommended:
- Time and Adaptation: For the user experiencing "skin tingling" and temperature dysregulation, they noted, "My body adapted after maybe 6 weeks?