Systemic Allergic Reactions (Itching, Rash, Hives)
Users on Reddit have reported experiencing systemic allergic reactions such as itching, rash, and hives while on GLP-1 medications. These reactions can vary in intensity and presentation.
Experiences with Systemic Allergic Reactions:
Another user, on their third month of Zepbound, reported their injection site getting "itchy a few days after injecting," developing a "little red bump almost like a mosquito bite" which then fades into a scar-like mark. This did not happen in the first two months. [2] This user also mentioned that they've "searched things up and see it’s normal when on the 5mg. "[3]
A different user on Zepbound also experienced their first injection site reaction with their first 7. 5mg dose, describing it as "blotchy red with an irregular shape and slightly itchy. "[4]
A user mentioned that "Hypersensitivity Reactions: Anaphylactic reactions and angioedema have been reported postmarketing. Discontinue WEGOVY if suspected and promptly seek medical advice (5. 6). " This is from a list of potential side effects, not a personal experience, but indicates awareness of such reactions. [5]
A user on thyroid medication (not GLP-1, but relevant to allergy discussion) described their allergies showing up as "flu symptoms (like having the flu every day) as well as intense sinusitis. " While not a GLP-1 specific reaction, it highlights how allergic reactions can manifest. [6]
The Zepbound subreddit's automated message lists "Injection Site Reactions" and "Allergic reactions" as common side effects. [7]
Remedies and Preventions Recommended:
Topical Ointments: A user mentioned, "I think some people apply anti-itch or antihistamine ointments to control it after the injection" for injection site reactions. [8]
Rotating Injection Sites: When asked if they were moving injection sites, a user experiencing reactions replied, "I move them around! I switch from both arms to my stomach every week. "[3] This is a general recommendation for injections, though not specifically stated as a remedy for the allergic reaction itself in this context.
Discontinuation: The prescribing information for Wegovy, as cited by a user, advises to "Discontinue WEGOVY if suspected [hypersensitivity reactions] and promptly seek medical advice. "[5]
It's important to note that some users report that these reactions, like itchy bumps at the injection site, may fade over time. One user stated, "The scar will disappear,"[9] and another said, "They do go away.
Experiences with Systemic Allergic Reactions:
- One user described starting to get an "allergic reaction to the injections" which contributed to their overall negative experience with the medication.
Remedies and Preventions Recommended:
- Antihistamines: One user stated they "Need to take regular gavascon, fiber and antihistamine" while on the medication, suggesting antihistamines for managing allergic reactions.
It's important to note that some users report that these reactions, like itchy bumps at the injection site, may fade over time. One user stated, "The scar will disappear,"[9] and another said, "They do go away.